Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity.
By D. Kirkland, M. Aardema, L. Henderson, L. Müller. Mutation research, 2005
758 citations recorded by the source corpus.
Subfields: Cancer Research, Health, Toxicology and Mutagenesis, Small Animals
View Paper: https://www.semanticscholar.org/paper/841ed75753f7ff7a1f74334b23acceb122fead1d
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Citations in the corpus
- Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients. (2015, positive): “Concerning genotoxicity it has to be taken into account that the current battery of in vitro tests (Ames, and in vitro clastogenicity) has a very low specificity; it has been show that up to 90% of non-carcinogens are positive in at least one of these tests (Kirkland et al., 2005).”