Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

By Zhoutao Chen, A. Karaplis, S. Ackerman, I. Pogribny, S. Melnyk, S. Lussier‐Cacan, Moy‐Fong Chen, A. Pai, S. John, R. S. Smith and 6 more. Human Molecular Genetics, 2001

620 citations recorded by the source corpus.

Subfields: Hematology, Rheumatology, Surgery

View Paper: https://www.semanticscholar.org/paper/83b58a2e50bd6acb2a589fc6efd08b1392131451

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. A. Smith
2. C. Johnston
3. H. Refsum
4. P. Ueland
5. E. Nexo
6. N. Greene
7. J. Scott
8. C. McPartlin

Citations in the corpus

• Facts and recommendations about total homocysteine determinations: an expert opinion. (2004, background): “Data from knock-out mice support the view that increased Hcy causes vascular disease (146, 147).”
• The genetic basis of mammalian neurulation (2003, background): “Moreover, knockout of the important folate metabolic enzyme 5,10-methylene tetrahydrofolate reductas”