Spider Silk Fibers Spun from Soluble Recombinant Silk Produced in Mammalian Cells

By A. Lazaris, S. Arcidiacono, Yue-Jin Huang, J. Zhou, F. Duguay, N. Chrétien, E. Welsh, J. Soares, C. Karatzas. Science, 2002

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Biological materials: Functional adaptations and bioinspired designs (2012, background): “Mammalian cells have also been employed successfully to produce silks through recombinant technology [576].”
Recombinant Spider Silks—Biopolymers with Potential for Future Applications (2011, neutral): “The recombinant silk protein could easily be purified by a combination of heat treatment, acidification and ammonium sulfate precipitation [35,41].”
Current development of biodegradable polymeric materials for biomedical applications (2018, background): “One study has pointed to the transgenic expression of spider silk in plants (eg, tobacco and potato) or utilizing mammalian epithelial cells as a way to garner a more substantive production of silk, but so far, no solutions are in place.(171,172) Besides sustainability, the key to developing new sil”