Non-alcoholic fatty liver disease - A global public health perspective.

By Z. Younossi. Journal of Hepatology, 2019

1,855 citations recorded by the source corpus.

As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of NAFLD which can be characterised as non-alcoholic steatohepatitis (NASH) is a potentially progressive liver disease that can lead to cirrhosis, hepatocellular carcinoma, liver transplantation, and death. NAFLD is also associated with extrahepatic manifestations such as chronic kidney disease, cardiovascular disease and sleep apnoea. NAFLD and NASH carry a large economic burden and create poor health-related quality of life. Despite this important burden, we are only beginning to understand its mechanisms of pathogenesis and the contribution of environmental and genetic factors to the risk of developing a progressive course of disease. Research is underway to identify appropriate non-invasive diagnostic methods and effective treatments. Although the risk of liver-related mortality is increased in patients with NAFLD and liver fibrosis stages F3 or F4, the leading cause of death is cardiovascular disease. Given the rapidly growing global burden of NAFLD and NASH, efforts must continue to find accurate non-invasive diagnostic and prognostic biomarkers, to develop effective treatments for individuals with advanced NASH and prevention methods for individuals at high risk of NAFLD and progressive liver disease.

Subfields: Epidemiology, Hepatology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/8395881647971581c7a9a0fd2be6d606d0ac7394

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Sarkar
2. Saranya Chidambaranathan-Reghupaty
3. P. Fisher

In Hepatology

1. D. Sarkar
2. Saranya Chidambaranathan-Reghupaty
3. P. Fisher

Citations in the corpus

• Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification (2020, background): “Obesity and diabetes are two major risk factors for NAFLD, and the increase in NAFLD cases in the past decade parallels an increase in the worldwide incidence of obesity and diabetes (Younossi, 2019).”