A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

By M. Boyce, Kevin F. Bryant, C. Jousse, Kai Long, H. Harding, D. Scheuner, R. Kaufman, D. Ma, D. Coen, D. Ron and 1 more. Science, 2005

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond (2012, background): “This regulatory loop can be modulated by specific drugs to alleviate ER stress, with great therapeutic potentia”
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014, background): “Salubrinal and guanabenz, two structurally unrelated small molecular compounds, have been identified to prevent the dephosphorylation of eIF2 by disrupting PP1 complex, thereby sustaining PERK-ATF4 signaling during ER stress (15,165).”
The impact of the unfolded protein response on human disease (2012, background): “In addition, selective inhibitors of eIF2 dephosphorylation that target GADD34 can rescue cells from protein misfolding stress (Boyce et al., 2005; Tsaytler et al., 2011).”