Pharmacokinetic issues for antibiotics in the critically ill patient

By J. Roberts, J. Lipman. Critical Care Medicine, 2009

828 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/836d2ab526f461ce6093b8153c12f2ba12725bb3

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1. R. Nau
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Citations in the corpus

• Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections (2010, background): “In critically ill patients, hydrophilic antibiotics (e.g., -lactams, aminoglycosides, and glycopeptides) often have an increased volume of distribution (lowering serum concentrations and AUCS) and a reduced drug clearance (increasing serum concentrations and AUCS) (207).”