Discovery and annotation of long noncoding RNAs

By John S. Mattick, Johannes Rinn. Nature Structural &Molecular Biology, 2015

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FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome (2017, methodology): “This naturally leads to the annotation of two high-confident classes of lncRNAs and mRNAs and also to the definition of a third class of ambiguous transcripts (i.e. transcripts whose the CPS is between the two cut-offs) that are named TUCp (34,40) for Transcripts of Unknown Coding potential (Figure ”
Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “, 2014), whereas up to 70% of the human genome is transcribed into RNA, yielding many thousands of non-coding RNAs (Derrien et al., 2012; Mattick and Rinn, 2015).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “This length threshold is a simple but convenient biophysical cut-off that separates lncRNAs from smaller ncRNA species such as miRNAs, siRNAs, and others (184, 197).”