Viral dynamics in mild and severe cases of COVID-19

By Yang Liu, Li-meng Yan, La-gen Wan, T. Xiang, Aiping Le, Jiaming Liu, M. Peiris, L. Poon, Wei Zhang. Lancet. Infectious Diseases (Print), 2020

1,584 citations recorded by the source corpus.

www.thelancet.com/infection Published online March 19, 2020 https://doi.org/10.1016/S1473-3099(20)30232-2 1 day of disease onset at the time of sampling. The DCt values of severe cases remained significantly lower for the first 12 days after onset than those of corresponding mild cases (figure A). We also studied serial samples from 21 mild and ten severe cases (figure B). Mild cases were found to have an early viral clearance, with 90% of these patients repeatedly testing negative on RT-PCR by day 10 post-onset. By contrast, all severe cases still tested positive at or beyond day 10 postonset. Overall, our data indicate that, similar to SARS in 2002–03, Viral dynamics in mild and severe cases of COVID-19

Subfields: Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/83184ed0b758852cf8d08323b0e144f912249cd2

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In Epidemiology

Citations in the corpus

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions (2020, neutral): “Patients with high viral loads and long virus-shedding periods are at higher risk of severe COVID-19 [15] .”
COVID-19 and diabetes: Knowledge in progress (2020, neutral): “[16] Liu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, et al.”
Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations (2020, neutral): “65 This fact has significant implications for the use of isolation facilities.”
Virology, transmission, and pathogenesis of SARS-CoV-2 (2020, background): “30 32 In people with severe illness, increased plasma concentrations of inflammatory cytokines and biomarkers were observed compared with people with non-severe illness.”
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening (2020, neutral): “𝒪 𝒪 Viral loads appear to become undetectable by PCR within 3 weeks of symptom onset ( 45 , 48 , 50 ), but detectability and timing may differ, depending on the degree or presence of symptoms ( 50 , 51 ).”
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study (2020, background): “A study conducted in 76 Chinese COVID19 inpatients showed that high viral RNA load is associated with the severity of the disease [24].”
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options (2020, background): “At the same time, pronounced nucleic acid shedding of SARS-CoV-2 was observed for 7 days in mild cases.(15) To better appreciate the links between cardiovascular disease (CVD) and COVID-19, it is important to understand the underlying pathobiology of coronavirus infection.”