The Lack of Association Between Signs and Symptoms in Patients With Dry Eye Disease

By Kelly K. Nichols, J. Nichols, Md. Mph, G. Mitchell. Cornea, 2004

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TFOS DEWS II pain and sensation report (2017, unknown): “The lack of correlation between signs and symptoms of DED has made research and clinical practice challenging for many [417].”
The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. (2011, background): “Thus far, the Beijing Eye Study comes closest to this type of construct by reporting the prevalence of eyelid telangiectasia (as a clinical sign of MGD) in the presence of symptoms of dry eye.(26) At 69%, the reported prevalence was relatively high when compared to other studies that did not include”
The international workshop on meibomian gland dysfunction: report of the clinical trials subcommittee. (2011, background): “For the aqueous-deficient and non–aqueous-deficient dry eyes only, when a cutoff value of 20 mm was used, the calculated sensitivity and specificity were 86% and 83%, respectively.196,214 PRT was found not to have any correlation with MGD (in patients with more than grade 1 MGD as classified by Bron”