Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

By Jiong Cai, Lulu Sun, F. Gonzalez. Cell Host and Microbe, 2022

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SUMMARY Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become Westernized. New insights have been discovered with the development of various omics techniques, revealing that gut microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies revealed a link between microbial bile acid (BA) metabolism, IBD and CRC progression. Several BA-derived metabolites have recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation and tumorigenesis are discussed, together with human omics data to provide prospective insights into future prevention and therapy of IBD and CRC.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/82a8e706820faf6ece22f308ec3f880c0485e588