Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine

By E. Célèrier, C. Rivat, Y. Jun, J. Laulin, A. Larcher, P. Reynier, G. Simonnet. Anesthesiology, 2000

596 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology, Small Animals

View Paper: https://www.semanticscholar.org/paper/821f7ac7a691af4a6b4b4d29e18f1a210882fd46

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1. L. Manchikanti
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4. Hans C. Hansen
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Citations in the corpus

• A comprehensive review of opioid-induced hyperalgesia. (2011, background): “A progressive reduction in baseline nociceptive pain thresholds were illustrated with intrathecal morphine administration (32), with fentanyl boluses (33), and with repeated heroin administration (34).”
• Opioid-induced Hyperalgesia: A Qualitative Systematic Review (2006, background): “However, one of these studies demonstrated prolonged hyperalgesia that lasted up to 5days after a very high dose of fentanyl.(43) A second experiment administering a similarly high dose of fentanyl before injecting carrageenan into the hind paw demonstrated that hyperalgesia associated with hind paw”