The human tumor microbiome is composed of tumor type-specific intracellular bacteria
By D. Nejman, Ilana Livyatan, Garold Fuks, N. Gavert, Yaara Zwang, L. Geller, Aviva Rotter-Maskowitz, Roi Weiser, Giuseppe Mallel, Elinor Gigi and 51 more. Science, 2020
2,022 citations recorded by the source corpus.
Profiling tumor bacteria Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman et al. produced an exhaustive catalog of the bacteria present in more than 1500 human tumors representing seven different tumor types (see the Perspective by Atreya and Turnbaugh). They found that the bacteria within tumors were localized within both cancer cells and immune cells and that the bacterial composition varied according to tumor type. Certain biologically plausible associations were identified. For example, breast cancer subtypes characterized by increased oxidative stress were enriched in bacteria that produce mycothiol, which can detoxify reactive oxygen species. Science, this issue p. 973; see also p. 938 Different human tumor types show differences in the composition of bacteria that they harbor. Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients’ smoking status, and the response to immunotherapy.
Subfields: Biotechnology, Food Science, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/82180ed9a575d14728b643497a22604246263c18
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Citations in the corpus
- Hallmarks of Cancer: New Dimensions. (2022, background): “For example, in a survey of 1,526 tumors encompassing seven human cancer types (bone, brain, breast, lung, melanoma, ovary, and pancreas), each type was characterized by a distinctive microbiome that was largely localized inside cancer cells and immune cells, and within each tumor type, variations i”
- From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment. (2023, methodology): “Sequencing data from the tumor microbiomemight serve as a diagnostic tool for oncology as scientists learn more about the role of bacteria in cancer.(133) Data from the immune system, such as T cell receptor sequences, can also provide diagnostic clues for cancer based on the body’s response to tumo”
- The updated landscape of tumor microenvironment and drug repurposing (2020, background): “Thus, microbiome can directly interact with cancer, for instance, cervicovaginal microbiome for cervical or endometrial cancer and gut microbiome for gastrointestinal cancer.243 Microbiome is an emerging acellular component in TME that can influence carcinogenesis, genomic instability, and therapies”
- The microbiome and human cancer (2021, methodology): “used quantitative polymerase chain reaction (qPCR) of 16S ribosomal RNA (rRNA) to estimate the number of bacteria relative to 40 ng of DNA inmelanoma, lung, ovarian, glioblastoma, pancreatic, bone, and breast cancer tissue sections (12).”