Moving on up: can results from simple aquatic mesocosm experiments be applied across broad spatial scales?

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Mesocosm Experiments as a Tool for Ecological Climate-Change Research (2013, background): “…since then, the use of mesocosms has proliferated, despite debate on their value relative to other experimental approaches, 93Mesocosm Experiments as a Tool for Ecological Climate-Change Research particularly whole-ecosystem experiments (Schindler, 1998 and references therein; Spivak et al., 2011).”
Harmful Cyanobacterial Blooms: Causes, Consequences, and Controls (2013, background): “Recent surveys of algal productivity in response to nutrient enrichment across geographically diverse eutrophic lakes, reservoirs, estuarine and coastal waters and a range of experimental enclosures (<1 L to over 10,000 L) reveal that strongest stimulation is routinely observed in response to both N”