The risk associated with aprotinin in cardiac surgery.

By D. Mangano, I. Tudor, Cynthia Dietzel. New England Journal of Medicine, 2006

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Misunderstandings between experimentalists and observationalists about causal inference (2008, methodology): “7.2. The balance test fallacy The practice of using hypothesis tests to evaluate balance is widespread and includes a large volume of otherwise high quality work in economics (Smith and Todd, 2005), political science (Imai, 2005), sociology (Lundquist and Smith, 2005), psychology (Haviland and Nagin”
ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiov (2007, background): “Early clinical experience suggested that the intraoperative use of aprotinin or tranexamic acid may permit surgery to be conducted safely on patients presenting while taking aspirin and clopidogrel (367,368); however, there is controversy regarding the safety of aprotinin in cardiac surgery (369).”
2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. (2011, background): “The wide-spread adoption of antifibrinolytic therapies for cardiac surgery stimulated concern over the safety and efficacy of these drugs [38, 63–69].”