Mechanisms of antibiotic resistance

By Jun Lin, K. Nishino, M. Roberts, M. Tolmasky, R. Aminov, Lixin Zhang. Frontiers in Microbiology, 2015

1,715 citations recorded by the source corpus.

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by a growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://

Subfields: Microbiology, Molecular Medicine, Pollution

View Paper: https://www.semanticscholar.org/paper/819473a93e29c22a39cee4286b1762d7249f15a0

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Citations in the corpus

Antimicrobial Resistance: A Growing Serious Threat for Global Public Health (2023, background): “The acquired resistance is most often transmitted through a plasmid acquired via conjugation, and it may be temporary or permanent [29,30].”
Antibiotic resistance: a rundown of a global crisis (2018, background): “Antibiotics may influence this process by inducing the transmission of resistance elements; these antimicrobials may additionally exert a selective pressure to the emergence of resistance.(37,38) Demonstration of transmission dynamics of resistance has increased the awareness and understanding of ho”
Bacteria Antibiotic Resistance: New Challenges and Opportunities for Implant-Associated Orthopaedic Infections (2017, background): “The molecular mechanisms of antibiotic resistance have been extensively reviewed.(14,18) There are two distinct types of antibiotic resistance: Intrinsic and acquired.”
Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications (2018, background): “In this view, bacteria prevaricate the inhibitory or bactericidal activities of the antibiotics, and execute resistance by either modifying or altering the target sites (ribosomes) for binding by antibiotics, with the help of ribosomal protection proteins which bind to the ribosomes, thereby prevent”
Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “Antibiotic resistance has very diverse mechanisms such a enzymatic mechanisms using by β-lactamases, acetyltransferases or aminoglycoside modifying enzymes [5].”