Design of polymeric nanoparticles for biomedical delivery applications
By Mahmoud Elsabahy, K. Wooley. Chemical Society Reviews, 2012
1,473 citations recorded by the source corpus.
Polymeric nanoparticles-based therapeutics show great promise in the treatment of a wide range of diseases, due to the flexibility in which their structures can be modified, with intricate definition over their compositions, structures and properties. Advances in polymerization chemistries and the application of reactive, efficient and orthogonal chemical modification reactions have enabled the engineering of multifunctional polymeric nanoparticles with precise control over the architectures of the individual polymer components, to direct their assembly and subsequent transformations into nanoparticles of selective overall shapes, sizes, internal morphologies, external surface charges and functionalizations. In addition, incorporation of certain functionalities can modulate the responsiveness of these nanostructures to specific stimuli through the use of remote activation. Furthermore, they can be equipped with smart components to allow their delivery beyond certain biological barriers, such as, skin, mucus, blood, extracellular matrix, cellular and subcellular organelles. This tutorial review highlights the importance of well-defined chemistries, with detailed ties to specific biological hurdles and opportunities, in the design of nanostructures for various biomedical delivery applications.
Subfields: Biomaterials, Molecular Biology, Polymers and Plastics
View Paper: https://www.semanticscholar.org/paper/8190d531d326e1adf364d1128398ee36d142e21d
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Citations in the corpus
- Insight into nanoparticle cellular uptake and intracellular targeting (2014, positive): “With some nanomedicines alreadymaking their way into the clinic, liposomes, polymeric nanoparticles, dendrimers, and gold nanoparticles have demonstrated remarkable potential as carrier systems [5–8].”
- Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. (2016, background): “5 nm (hydrodynamic diameter), they can be eliminated through the renal pathway via the urine [122,123].”
- Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “Since the primary function of BBB is to block toxic agents to reach the brain, currently available chemotherapy agents for brain cancer are highly limited to intraventricular or intracerebral infusions [162].”
- Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, background): “drug delivery studies in the past years including chitosan, dextran, heparin, and hyaluronan [19].”