Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.

By Gerd Kempermann. 2015

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In Biomedical Engineering

Citations in the corpus

Variant interpretation using population databases: lessons from gnomAD (2021, methodology): “The gnomAD browser displays the mean proportion expressed across transcripts (pext) score, based on GTEx v7 data from 800 individuals (GTEx Consortium, 2015).”
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans (2017, neutral): “While previously suggested to regulate energy balance and glucose tolerance (37), GLP2R has primarily been implicated in gastrointestinal function (38,39).”
Network propagation: a universal amplifier of genetic associations (2017, background): “There has been promising research into developing such networks 84,95 , with important developments underway from the Genotype-Tissue Expression (GTEx) project, which enables the construction of a specific network for each major human tissue 96 .”
Tools and best practices for data processing in allelic expression analysis (2015, methodology): “However, given that most genes have eQTLs [4, 5, 8], biological sources of AE are expected to be extremely widespread, which is further supported by high heritability of AE [2].”
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences (2016, background): “The Genotype-Tissue Expression portal is a catalogue of human gene expression, eQTL, sQTL (splicing quantitative trait loci) and ASE data that can be used interactively to verify gene expression and gene expression regulation patterns in a variety of different tissues [59], while Braineac is a simil”
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis (2019, neutral): “Indeed, investigators have used nextgeneration sequencing technology (RNA-Seq) to develop an organ-level transcriptomic map of the human body (8).”
A data-driven approach to predicting successes and failures of clinical trials (2016, methodology): “The Gene RPKM RNA-Seq data from the Genotype-Tissue Expression (GTEx) project(Consortium, 2015) was downloaded from http://www.gtexportal.org/home/.”
Landscape of X chromosome inactivation across human tissues (2016, positive): “Patient RNA samples derived from primary muscle were sequenced using the GTEx sequencing protocol 12 with sequence coverage of 50M or 100M 76 bp paired-end reads.”