Statins Have Biphasic Effects on Angiogenesis

By M. Weis, C. Heeschen, Alexander J. Glassford, J. Cooke. Circulation, 2002

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Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. (2008, background): “Of note, HMG-CoA reductase inhibitor, statins which inhibit Rac1 activity [93] can block angiogenesis in vivo [94].”
Pleiotropic Effects of Statins on the Cardiovascular System (2017, background): “intensity statins are able to reduce intraplaque angiogenesis in patients with atherosclerosis.(137,138)”
Statins and cancer prevention (2005, background): “Statins significantly reduced tumour growth and tumour vascularization in the Lewis lung cancer mode”
Hormesis: Why it is important to toxicology and toxicologists (2008, background): “The statin drug family [166] is known for its capacity to enhance capillary formation and, thereby, possibly increase cancer risks in affected tissues.”
Pleiotropic effects of statins. (2005, background): “At higher concentrations, statins appear to have an anti-angiogenic effect (77,78), suggesting a biphasic effect of statins on angiogenesis (79).”