A Cinderella Caspase Takes Center Stage

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Caspase family proteases and apoptosis. (2005, background): “... a new question: In the mitochondrionmediated activation pathway of apoptosis, which caspase is the first to be activated, caspase-2 or caspase-9? These new results also gave rise to the new proposal that Bcl-2 may act as CED-9, inhibiting apoptosis through inhibiting the activation of procaspase”