Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.

By L. Ware, Michael A. Matthay. American Journal of Respiratory and Critical Care Medicine, 2001

909 citations recorded by the source corpus.

Subfields: Epidemiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/810752c5b81a5da3b3694740cbf91c1fc77d5609

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Donald E. Ingber
2. Michael A. Matthay

In Pulmonary and Respiratory Medicine

1. Michael A. Matthay
2. G. Zimmerman
3. Arthur S Slutsky
4. N. Gupta
5. V. Serikov
6. Donald E. Ingber
7. R. Zemans

Citations in the corpus

• Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment (2018, background): “Because injury to the alveolar epithelium is an important cause ofARDS, accelerationofalveolarepithelial repairmay facilitate resolution of pulmonary edema and lung injury.(46)Keratinocyte growth factor (KGF) is important in alveolar epithelial repair, and experimental and human studies(47) support ”
• A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice (2012, background): “There are, however, still important physiological processes, such as reabsorption and clearance of fluid in the alveolar air space (42, 43), that could be further studied to determine their relative contribution to development of pulmonary edema in this microengineered model system.”
• Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome* (2006, background): “This explanation is attractive because recent evidence (33) indicates that PAI-1 impairs alveolar epithelial repair, a critical step in successful recovery from ALI/ARDS (28, 34).”
• Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung (2009, background): “Impaired AFC in patients with ALI/ARDS is associated with higher morbidity and mortality (5, 6).”
• Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. (2005, background): “The transport capacity of the alveolar epithelium is markedly diminished in ALI, a finding that correlates with higher mortality (19, 20).”