Simultaneous Reduction and Surface Functionalization of Graphene Oxide for Hydroxyapatite Mineralization

By Hongyan Liu, Pinxian Xi, Guoqiang Xie, Yanjun Shi, Fengping Hou, Liang Huang, Fengjuan Chen, Z. Zeng, Changwei Shao, Jun Wang. 2012

200 citations recorded by the source corpus.

In this study, we present the synthesis of reduced graphene oxide/hydroxyapatite (RGO/HA) hybrid materials by an environmental-friendly route. Graphene oxide (GO) was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine (PDA). The bioinspired surface was further used for biomimetic mineralization of hydroxyapatite. When incubated in a simulated body fluid (SBF), the PDA layer enabled efficient interaction between the RGO surface and the mineral ions to improve the bioactivity, promoted the formation of the HA nanoparticles. A detailed structural and morphological characterization of the mineralized composite was performed. The HA-based hybrid materials exhibited no cytotoxic effect on L929 fibroblast cells, showing potential capacity of being a scaffold material for bone tissue regeneration and implantation. This facile strategy also can be a useful platform for other RGO-based nanocomposites.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/80dcc9aaab11304c6badaa13bc64f093e555b6b5

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In Biomaterials

1. Yan Cheng
2. Yufeng Zheng
3. T. Xi

Citations in the corpus

• Graphene oxide/hydroxyapatite composite coatings fabricated by electrophoretic nanotechnology for biological applications (2014, background): “[21–23], biomimetic mineralization process [24,25], spark plasma sintering (SPS) technique [26], radio-frequency chemical vapor deposition [27], electrospinning method [28] and so on.”