Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

By Z. Younossi, F. Tacke, M. Arrese, Barjesh Chander Sharma, I. Mostafa, E. Bugianesi, V. Wai‐Sun Wong, Y. Yılmaz, J. George, Jian-Gao Fan and 1 more. Hepatology, 2019

1,574 citations recorded by the source corpus.

Over the past 2 decades, nonalcoholic fatty liver disease (NAFLD) has grown from a relatively unknown disease to the most common cause of chronic liver disease in the world. In fact, 25% of the world’s population is currently thought to have NAFLD. Nonalcoholic steatohepatitis (NASH) is the subtype of NAFLD that can progress to cirrhosis, hepatocellular carcinoma (HCC), and death. NAFLD and NASH are not only found in adults—there is also a high prevalence of these diseases in children and adolescents. Because of the close association of NAFLD with type 2 diabetes (T2DM) and obesity, the latest models predict that the prevalence of NAFLD and NASH will increase, causing a tremendous clinical and economic burden and poor patient‐reported outcomes. Nonetheless, there is no accurate noninvasive method to detect NASH, and treatment of this disease is limited to lifestyle modifications. To examine the state of NAFLD among different regions and understand the global trajectory of this disease, an international group of experts came together during the 2017 American Association for the Study of Liver Diseases Global NAFLD Forum. We provide a summary of this forum and an assessment of the current state of NAFLD and NASH worldwide.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/805587f1658fdfa651396c99113d654152382eb7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. S. Friedman
2. Gerald I. Shulman
3. R. Loomba

In Epidemiology

1. S. Friedman
2. Gerald I. Shulman
3. R. Loomba
4. Y. Saiman
5. J. Puche
6. J. Bonner
7. D. Clegg
8. B. Palmer

In Hepatology

1. S. Friedman
2. Gerald I. Shulman
3. R. Loomba
4. Y. Saiman
5. J. Puche
6. J. Bonner

Citations in the corpus

• Mechanisms and disease consequences of nonalcoholic fatty liver disease (2021, background): “Epidemiology of NAFLD NAFLD is estimated to afflict one billion individuals globally and may be present in approximately 25% of the world population (Younossi et al., 2019b).”