Bone Morphogenetic Proteins Stimulate Angiogenesis through Osteoblast-Derived Vascular Endothelial Growth Factor A.

By M. Deckers, R. van Bezooijen, G. van der Horst, J. Hoogendam, C. van der Bent, S. Papapoulos, Clemens W G M Lo Wik. Endocrinology, 2002

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Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation (2003, background): “, 2002] and also express VEGF related receptors and proteins [Harper et al., 2001; Deckers et al., 2002].”
Extracellular control of TGFβ signalling in vascular development and disease (2007, background): “TGFβ family members can also act in a paracrine manner by stimulating the production of pro-angiogenic cytokines, such as vascular endothelial growth factor (VEGF), TGFα and monocyte chemoattractant protein-1 (MCP1”
Osteogenesis and angiogenesis: the potential for engineering bone. (2008, background): “Indirectly, osteogenic factors such as BMP-2 can stimulate osteoblast VEGF and hence modulate vascularisation (Deckers et al., 2000).”
Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds (2014, positive): “Crosstalk between endothelial cells and osteoblasts is essential for bone formation [6,7].”
Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis (2008, background): “progression of fracture repair, and this effect can be rescued by the addition of exogenous VEGF ( Colnot et al. , 2003 ), suggesting that angiogenesis is linked to the apoptosis of chondrocytes.”