Faculty Opinions recommendation of The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.
By J. Rizo. 2003
131 citations recorded by the source corpus.
Subfields: Biophysics, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/7fe6c9bb71092819471a5194212561efc773c436
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In Biophysics
In Cellular and Molecular Neuroscience
Citations in the corpus
- Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013, background): “…to the Syt1 C2A domain decrease Ca2+-triggered synchronous release in hippocampal neurons by approximately 50% but do not ablate it, whereas mutations that block Ca2+ binding to the C2B domain ablate fast synchronous release (Mackler et al., 2002; Nishiki and Augustine, 2004; Shin et al., 2009).”