Uninterrupted MCM2-7 function required for DNA replication fork progression.

By K. Labib, J. A. Tercero, J. Diffley. Science, 2000

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Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis (2000, background): “This idea has been recently reinforced by the finding that yeast MCM proteins are required for replication fork progression (32) and by the characterization of a processive helicase activity in an archaeal MCM protein (5, 29).”
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. (2006, neutral): “Varshavsky and coworkers then isolated a temperature-sensitive dihydrofolate reductase degron with a greatly reduced half-life at nonpermissive temperatures (Dohmen et al., 1994), enabling studies of essential proteins in yeast (Labib et al., 2000; Kanemaki et al., 2003).”