Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation
By K. Atarashi, W. Suda, Chengwei Luo, T. Kawaguchi, Iori Motoo, S. Narushima, Yuya Kiguchi, Keiko Yasuma, E. Watanabe, Takeshi Tanoue and 16 more. Science, 2017
827 citations recorded by the source corpus.
Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn's disease (CD), are associated with imbalances in the gut microbe community. The causes of these intractable diseases have been difficult to discern. Atarashi et al. took samples from the mouths of IBD and CD patients and inoculated the extracted bacteria into germ-free mice (see the Perspective by Cao). Some of the inoculated mice showed strong proliferation of T helper 1 cells associated with the establishment of oral Klebsiella species in the colon. Klebsiella can be resistant to multiple antibiotics and are able to replace normal colon microbes after antibiotic therapy. Now we know that they probably originate from the mouth and could potentially contribute to bowel disease. Science, this issue p. 359; see also p. 308 The mouth may act as a reservoir for intestinal disease-causing bacteria. Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.
Subfields: Infectious Diseases, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/7ec024825b20f255f9595cfbda5b0fceb6342ae4
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Citations in the corpus
- Oral microbiomes: more and more importance in oral cavity and whole body (2018, background): “…from IBD patients, and there are also a number of questions that need to be solved such as possible differences between CD and UC, and on the influence of other factors such as age, diet and medication on microbial dysbiosis associated with IBD (Lucas López et al., 2017; Atarashi et al., 2017).”
- Interaction between microbiota and immunity in health and disease (2020, background): “derived from IBD patients, induces Th1-type intestinal inflammation in IL10 mice.(166) Furthermore, abnormal T cell and B cell adaptive immunity can be transmitted to GF mice from infantharbored microbiome born to IBD-prone mothers.”
- Microbiota in health and diseases (2022, background): “Recent studies also suggested that intestinal colonization of oral microbiota contributes to several health issues including carcinogenesis.(155) F.”