CTCF/cohesin-binding sites are frequently mutated in cancer

By Riku Katainen, Kashyap Dave, E. Pitkänen, Kimmo Palin, Teemu Kivioja, Niko Välimäki, A. Gylfe, H. Ristolainen, Ulrika A. Hänninen, Tatiana Cajuso and 12 more. 2015

430 citations recorded by the source corpus.

Subfields: Artificial Intelligence, Atomic and Molecular Physics, and Optics, Statistical and Nonlinear Physics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Artificial Intelligence

1. Chip Stewart
2. Tong Ihn Lee
3. Anton J. Enright
4. Catherine J. Wu
5. Gad Getz
6. Richard A. Young
7. W.J. Greenleaf

In Statistical and Nonlinear Physics

1. Anton J. Enright
2. Martin Hemberg

Citations in the corpus

• Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, methodology): “(43) by using antibodies for CEBPB andMAX (and Santa Cruz Biotechnology cat.”
• Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma (2016, background): “862 Cell Reports 15, 857–865, April 26, 2016 frequently mutated in CRC and positively selected in MSS tumors (Katainen et al., 2015).”
• Activation of proto-oncogenes by disruption of chromosome neighborhoods (2015, background): “A recent study noted that mutations in CTCF binding sites occur frequently in cancers (23), but it is unclear if mutations in boundaries are common as only a subset of CTCF sites form insulated neighborhoods (8, 10, 24).”
• Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci (2016, background): “…important developmental genes are positioned and regulated at such boundaries (Fabre et al., 2015) and these structures can be especially implicated in developmental diseases and cancer (Hnisz et al., 2016; Ibn-Salem et al., 2014; Katainen et al., 2015; Lupianez et al., 2015; Maass et al., 2012).”
• The chromatin accessibility landscape of primary human cancers (2018, background): “However, these mutations were relatively rare and often had only small effects on the accessibility of the CTCF motif site despite a known enrichment of somatic mutations in CTCF motif sites in cancer (51, 52).”
• Epigenetic plasticity and the hallmarks of cancer (2017, background): “Indeed, frequentmutations of CTCFmotifs in the vicinity of oncogenes have been reported in colorectal, liver, and esophageal cancer (50, 51).”
• Transcriptional Addiction in Cancer (2017, positive): “Thus, the CTCF DNA-binding motif in loop anchor regions is among the most altered human transcription factor-binding sequences in cancer cells (Hnisz et al., 2016b; Ji et al., 2016; Katainen et al., 2015).”
• Regulation of disease-associated gene expression in the 3D genome (2016, positive): “…comes from studies showing that CTCF and the cohesin subunits are frequently mutated in cancer 131–134 , that CTCF and cohesin haploinsufficient mice are predisposed to cancer 135–137 and that CTCF­ and cohesion­binding sites accumu­ late mutations in multiple different cancer types 100,139,140 .”