Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage.
By A. Webb, R. Bond, P. Mclean, R. Uppal, N. Benjamin, A. Ahluwalia. Proceedings of the National Academy of Sciences of the United States of America, 2004
634 citations recorded by the source corpus.
Subfields: Biophysics, Pathology and Forensic Medicine, Physiology
View Paper: https://www.semanticscholar.org/paper/7e5a7ec6b15e0bc5febf38d6d018daa98b74d313
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In Physiology
Citations in the corpus
- Methods to detect nitric oxide and its metabolites in biological samples. (2007, background): “The nitrite reductase activity in mammalian tissues has been linked to the mitochondrial electron transport system [17-21], protonation [16,22], deoxyhemoglobin [22,23], and xanthine oxidase [24-26].”
- Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. (2005, neutral): “…nitrite reduction can occur at very low oxygen tensions and has recently been suggested to mediate nitrite-dependent cytoprotection in a Langendorff heart I/R model (52), NO production from this system is detectable only in the presence of high concentrations of superoxide dismutase (53, 54).”
- The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. (2008, background): “A picture is now emerging suggesting important physiological functions of the nitrite-NO pathway in regulation of blood flow [6,7], gastric integrity [8–11] and in tissue protection against ischemic injury [12,13].”
- Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. (2010, background): “For example, it is possible that the protective effect of NO2 on infarct size that has been reported in experimental models of myocardial ischemia (20, 63, 73) might be due to an NO-mediated reduction in the energy (and O2) cost of contraction rather than, or perhaps in addition to, enhanced perfusi”
- Reperfusion injury and reactive oxygen species: The evolution of a concept (2015, background): “The protective effect of nitrite-derived NO in heart [176,177], kidney [178], lung [179], and liver [180] models of I/R injury are not observed following inhibition of XO with either allopurinol or oxypurinol, suggesting that the enzyme plays a critical role in the generation of NO by NO2 −.”