Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes
By Lihua Zhu, Zhi‐Gang She, Xu Cheng, Juan-Juan Qin, Xiao-Jing Zhang, Jingjing Cai, Fang Lei, Hai-tao Wang, Jing Xie, Wenxin Wang and 34 more. Cell Metabolism, 2020
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Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.
Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/7e25869a49cb3c6863e56448070da65346eee77b
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Citations in the corpus
- Comorbidity and its Impact on Patients with COVID-19 (2020, background): “In a cohort study of 7337 patients with COVID-19 with and without type 2 diabetes, it was shown that those with type 2 diabetes required increased interventions for their hospital stay versus those that were nondiabetic [28].”
- Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships (2020, background): “Importantly, uncontrolled serum glucose has been shown to significantly increase COVID-19 mortality.(116) During”