Targeting the translation machinery in cancer

By M. Bhat, Nathaniel Robichaud, Laura Hulea, Nahum Sonenberg, J. Pelletier, I. Topisirovic. Nature reviews. Drug discovery, 2015

741 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7dfceb65b700b236c4a8e058281ede8e07ac4ae4

How researchers see this paper

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In Molecular Biology

1. Min Wu
2. Nahum Sonenberg
3. David M. Sabatini
4. M. Karin
5. A. Budanov

Citations in the corpus

• mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “recognition by eukaryotic initiation factor 4F (eIF4F) and the assembly of the preinitiation complex (PIC), which consists of the ternary complex, the 40S ribosomal subunit, eIF1, eIF1A, eIF3 and eIF5.(21) eIF4F consists of eIF4A, eIF4E and eIF4G, which facilitates PIC recruitment by eIF4E–cap and e”
• Translational Control in Cancer. (2018, background): “This can be achieved through a variety of complex molecular alterations that increase selective translation of poorly translated mRNAs, including increased expression or availability of certain translation initiation factors, and increased activity of signaling pathways regulating them (reviewed in ”