Single Molecule Tip-Enhanced Raman Spectroscopy with Silver Tips
By Weihua Zhang, B. Yeo, A. Schmid, R. Zenobi. 2007
324 citations recorded by the source corpus.
We present single molecule tip-enhanced resonance Raman spectra from brilliant cresyl blue (BCB) submonolayers adsorbed on a planar Au surface with Ag tips. A gap of 1 nm between a Ag tip and the Au substrate was employed to create a highly enhanced electric field and to generate Raman scattering from an area of ∼100 nm2. Three lines of evidence are presented to prove the single molecule sensitivity of our experiments: (1) Extremely diluted samples were used. Estimations show that at most a few molecules were excited by the Ag tip. (2) Spectroscopic fluctuations, including intensity fluctuations, frequency shifts, and line shape changes were observed. A histogram analysis of the intensity fluctuations of two different BCB coverages was carried out. The results clearly show the features of single molecule behavior. (3) Discrete signal losses also were observed. This is because of photochemical processes involving single molecules. Besides BCB, which shows a strong resonant absorption at 633 nm (the wavele...
Subfields: Biomedical Engineering, Electronic, Optical and Magnetic Materials
View Paper: https://www.semanticscholar.org/paper/7de1a7e8a763b3a392a2837ff8cc13889e019b74
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In Biomedical Engineering
In Electronic, Optical and Magnetic Materials
Citations in the corpus
- Pressure-assisted tip-enhanced Raman imaging at a resolution of a few nanometres (2009, unknown): “Recent advances in tip-enhanced Raman spectroscopy and microscopy have demonstrated high sensitivity down to the single molecular leve”
- Tip-enhanced Raman spectroscopy: principles and applications (2015, methodology): “About a decade later single molecule sensitivity on a length scale of 10 nm was reported using TERS [118, 119].”
- Raman Techniques: Fundamentals and Frontiers (2019, background): “Gold shows strong enhancement factors in the red spectral region [111, 177, 211, 212], silver in the blue-green spectral region [132, 213] and aluminium in the UV and deep UV spectral regions [150, 151, 175].”