Host cell-intrinsic innate immune recognition of SARS-CoV-2
By E. A. Madden, Michael S. Diamond. 2021
46 citations recorded by the source corpus.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of 2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical investigations indicate that severe forms of COVID-19 are due in part to dysregulated immune responses to virus infection. The innate immune system is the first line of host defense against most virus infections, with pathogen recognition receptors detecting SARS-CoV-2 RNA and protein components and initiating pro-inflammatory and antiviral responses. Notwithstanding this response, SARS-CoV-2 proteins evade, inhibit, and skew innate immune signaling early in infection. In this review, we highlight the components of cell-based recognition of SARS-CoV-2 infection and the mechanisms employed by the virus to modulate these innate immune host defense pathways.
Subfields: Immunology, Infectious Diseases
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Infectious Diseases
Citations in the corpus
- The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, positive): “This multidomain protein is essential for effective host response to the most significant viral health threats impacting society today, including coronaviruses, influenza, flaviviruses, andmany more (Chen et al., 2016; Chiale et al., 2022; Diamond and Kanneganti, 2022; Fitzgerald et al., 2014;Madden”