Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

By S. Scales, F. D. de Sauvage. TIPS - Trends in Pharmacological Sciences, 2009

663 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/7d6b138a45efdb72a1f2e143a3bc200041613702

How researchers see this paper

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In Molecular Biology

1. Xiaochun Li
2. Xiaofeng Qi

In Pathology and Forensic Medicine

1. Xiaochun Li
2. Xiaofeng Qi

Citations in the corpus

• Targeting cancer stem cell pathways for cancer therapy (2020, background): “[599] [600] [601] Vismodegib was the first proposed Hh pathway inhibitor in cancer research 602 and is approved by the FDA 603 for local or advanced metastatic basal cell carcinoma treatment.”
• Mechanistic insights into the generation and transduction of Hedgehog Signaling (2020, background): “The Hedgehog (HH) signaling pathway plays a vital role in developmental patterning of animal embryogenesis and regeneration of adult tissues [1–4], and the HH ligand functions in a paracrine signaling (see Glossary) manner to regulate the HH signaling pathway [5].”