Cell type-specific activity in prefrontal cortex during goal-directed behavior
By L. Pinto, Y. Dan. 2015
293 citations recorded by the source corpus.
SUMMARY The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca2+ imaging from genetically defined cell types in the dorsomedial PFC of mice performing a PFC-dependent sensory discrimination task. We found that inhibitory interneurons of the same subtype were similar to each other, but different subtypes preferentially signaled different task-related events: somatostatin-positive neurons primarily signaled motor action (licking), vasoactive intestinal peptide-positive neurons responded strongly to action outcomes, whereas parvalbumin-positive neurons were less selective, responding to sensory cues, motor action, and trial outcomes. Compared to each interneuron subtype, pyramidal neurons showed much greater functional heterogeneity, and their responses varied across cortical layers. Such cell-type and laminar differences in neuronal functional properties may be crucial for local computation within the PFC microcircuit.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
Citations in the corpus
- Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data (2018, unknown): “This technique has been widely used to study the neural circuits in cortical, subcortical, and deep brain areas, such as hippocampus (Cai et al., 2016; Ziv et al., 2013; Jimenez et al., 2018; Rubin et al., 2015), entorhinal cortex (Kitamura et al., 2015; Sun et al., 2015), hypothalamus (Jennings et ”
- Adolescence as a neurobiological critical period for the development of higher-order cognition (2018, unknown): “Second, PV interneurons fire in response to diverse stimuli including sensory cues, motor action, and trial outcomes (Pinto and Dan, 2015; Rudy et al., 2011).”