Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)

By A. Paniz‐Mondolfi, C. Bryce, Z. Grimes, R. Gordon, J. Reidy, J. Lednicky, E. Sordillo, M. Fowkes. Journal of Medical Virology, 2020

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Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS‐CoV‐2.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/7d2280af2576122596e23fa683c5eed2bb83f32a

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Citations in the corpus

• COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection (2021, background): “Moreover, detection of SARS-CoV-2 in postmortem samples of frontal lobe [49] and cerebrospinal fluid [50] confirmed the virus neurotropic potential.”