Zwitterionic Biomaterials.

By Qingsi Li, Chiyu Wen, Jing Yang, Xianchi Zhou, Yingnan Zhu, Jie Zheng, Gang Cheng, J. Bai, Tong Xu, J. Ji and 3 more. Chemical Reviews, 2022

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The term "zwitterionic polymers" refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these oppositely charged groups are equally distributed at the molecular level, the molecules exhibit an overall neutral charge with a strong hydration effect via ionic solvation. The strong hydration effect constitutes the foundation of a series of exceptional properties of zwitterionic materials, including resistance to protein adsorption, lubrication at interfaces, promotion of protein stabilities, antifreezing in solutions, etc. As a result, zwitterionic materials have drawn great attention in biomedical and engineering applications in recent years. In this review, we give a comprehensive and panoramic overview of zwitterionic materials, covering the fundamentals of hydration and nonfouling behaviors, different types of zwitterionic surfaces and polymers, and their biomedical applications.

Subfields: Biomaterials, Polymers and Plastics, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/7cd36d998ce811616961b8b996a6e4aa5a19faa8