Transcriptional enhancers: from properties to genome-wide predictions

By Daria Shlyueva, Gerald Stampfel, Alexander Stark. Nature reviews genetics, 2014

1,323 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7cb939c2eddcb18685efc5fec4d80eaa8435550d

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In Molecular Biology

Citations in the corpus

Learning the human chromatin network from all ENCODE ChIP-seq data (2015, background): “Active enhancers are known to be flanked by histones marked by a combination of H3K27ac and H3K4me1 [58].”
Systematic mapping of functional enhancer-promoter connections with CRISPR interference (2016, background): “Regulatory elements do not necessarily affect the closest gene, but instead may act across long distances (7, 8).”
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “The impacts of lncRNA epigenetic alterations can be studied using a repurposing of HM450 probes to analyze lncRNA promoters and comparing the lncRNA DNA methylation profile of lncRNA promotors to an existing database.(265,283) In fact, several studies identified lncRNA copy-number alterations and ex”
Regulation of disease-associated gene expression in the 3D genome (2016, neutral): “The binding of specific transcription factors and the production of small enhancer RNAs are also part of the chromatin signature (for comprehensive reviews, see REFS 22–24 ).”
Deep Feature Selection: Theory and Application to Identify Enhancers and Promoters (2015, background): “H3K4me1 Enriched in enhancer regions [21].”
GeneHancer: genome-wide integration of enhancers and target genes in GeneCards (2017, background): “The accurate identification of enhancers is challenging (13), but recent progress has provided several relevant avenues to explore.”