Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
By Jérôme Galon, Daniela Bruni. Nature reviews. Drug discovery, 2019
2,840 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/7cad6bedf34432e909a59ef806a7edd5a8a8149e
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In Immunology
Citations in the corpus
- Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “RCD in chemotherapy, radiotherapy, and targeted therapy In addition to cold tumors infiltrated by immunosuppressive cells, immune desert tumors are also less responsive to immunotherapy due to their low immunogenicity and lack of immune cell infiltration, therefore, radiotherapy, chemotherapy, and t”
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020, neutral): “First, the tumor microenvironment and its constituent cellular interactions—accessible to HTAN through spatial and single-cell approaches—represent remarkable targeting opportunities for therapy (Binnewies et al., 2018; Galon and Bruni, 2019; Sharma et al., 2017).”
- Cytotoxic CD8+ T cells in cancer and cancer immunotherapy (2020, background): “The WNT/β-catenin signalling pathway participates in the regulation of the NF-κB and TGF-β pathways and downregulates the expression of interferon regulatory factor 3, a transcription factor essential for the differentiation and maturation of immune cells, and is therefore instrumental for the exclu”
- TROP2 expression in head and neck squamous cell carcinoma: association with the tumor immune microenvironment and clinical outcome (2026, unknown): “HNSCC is characterized by a highly heterogeneous immune landscape, with tumor-in fi ltrating lymphocytes, regulatory T cells, and macrophage subsets contributing to immune evasion and therapeutic response (20 – 22).”
- Intratumoral and peritumoral radiomics of MRIs predicts pathologic complete response to neoadjuvant chemoimmunotherapy in patients with head and neck squamous cell carcinoma (2024, unknown): “38 41 Some researchers tried to classify TME based on different density of immune cells within intratumoral and peri-tumoral area, which was shown to be associated with response to immunotherapy and prognosis of various types of cancers.”