Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
By Shaun Purcell, Naomi R. Wray, J. Stone, Peter M. Visscher, M. O’Donovan, Patrick F. Sullivan, P. Sklar. 2009
4,669 citations recorded by the source corpus.
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
Subfields: Genetics, Computational Biology & Bioinformatics
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- Alkes L Price
- Peter M. Visscher
- Frank Dudbridge
- Jian Yang
- Naomi R. Wray
- Michael E. Goddard
- Gibran Hemani
- Matthew Stephens
In Computational Biology & Bioinformatics
- Frank Dudbridge
- Peter M. Visscher
- M. Rockman
- Michael E. Goddard
- D. Curtis
- Ben J. Hayes
- Naomi R. Wray
- Jian Yang
Citations in the corpus
- LDpred2: better, faster, stronger (2020, background): “These scores have proven useful for studying the genetic architecture and relationships between diseases and traits (Purcell et al. 2009; Kong et al. 2018).”
- An Atlas of Genetic Correlations across Human Diseases and Traits (2015, methodology): “The two main existing techniques for estimating genetic correlation from GWAS data are restricted maximum likelihood (REML) [11, 12, 13, 14, 15, 16] and polygenic scores [17, 18].”
- Drosophila strategies to study psychiatric disorders. (2013, background): “Most psychiatric disorders are caused by multitudes of susceptibility genes, and variations in gene expression are as likely to be involved as actual mutations in the protein sequence of genes [27,83,99,136].”