Hypoxic control of metastasis
By Erinn B. Rankin, Amato J. Giaccia. Science, 2016
1,184 citations recorded by the source corpus.
Metastatic disease is the leading cause of cancer-related deaths and involves critical interactions between tumor cells and the microenvironment. Hypoxia is a potent microenvironmental factor promoting metastatic progression. Clinically, hypoxia and the expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are associated with increased distant metastasis and poor survival in a variety of tumor types. Moreover, HIF signaling in malignant cells influences multiple steps within the metastatic cascade. Here we review research focused on elucidating the mechanisms by which the hypoxic tumor microenvironment promotes metastatic progression. These studies have identified potential biomarkers and therapeutic targets regulated by hypoxia that could be incorporated into strategies aimed at preventing and treating metastatic disease.
Subfields: Cancer Research, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7c7208ae7f676afe4b7ee95982fba82e04f585f9
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Citations in the corpus
- The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “Due to the important role of HIF in cells, many studies have been performed to investigate the regulatory mechanism of HIF.(192,193) Among them, E3 ligases and DUBs have been found to regulate the stability of HIF.”
- Revisiting the hallmarks of cancer. (2017, neutral): “Context-dependent (tissue- or tumor-specific) triggers include a number of growth factors [22], signaling pathways [109], tissue hypoxia [110], metabolic and mechanical stress, and matrix stiffness [111].”
- Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “Hypoxia is also known to induce metastasis (385).”
- EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “Indeed, the well-described contribution of hypoxia to metastasis may be substantially related to the production of LOX downstream of the transcription driven by hypoxia-inducible factor (HIF) (Rankin and Giaccia, 2016).”
- Cytotoxic CD8+ T cells in cancer and cancer immunotherapy (2020, background): “Hypoxia promotes immunosuppression and induces epithelial–mesenchymal transition by upregulating the expression of transcriptional repressors of E cadherin.(89,90) In cancer cells, hypoxia and autophagy have a variety of complicated and competing roles.”