Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria
By Xiaoning Li, S. M. Robinson, Akash Gupta, Krishnendu Saha, Ziwen Jiang, Daniel F. Moyano, Alimardani Sahar, M. Riley, Vincent Rotello. ACS Nano, 2014
659 citations recorded by the source corpus.
We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-drug-resistant pathogens. These AuNPs exhibited low toxicity to mammalian cells, and bacterial resistance was not observed after 20 generations. A strong structure–activity relationship was observed as a function of AuNP functionality, providing guidance to activity prediction and rational design of effective antimicrobial nanoparticles.
Subfields: Applied Microbiology and Biotechnology, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/7bfed9083ce30d5fe929a7232309f4f47b850ea2
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Citations in the corpus
- Effect of the size and shape of silver nanoparticles on bacterial growth and metabolism by monitoring optical density and fluorescence intensity (2017, neutral): “Various nanomaterials including zeolite and Au have been studied for the treatment of antibiotic-resistant bacteria [2,3].”
- Attachment efficiency of gold nanoparticles by Gram-positive and Gram-negative bacterial strains governed by surface charges (2019, background): “agents (Bresee et al. 2011; Li et al. 2014; Ramasamy et al. 2014), or for photothermal therapy and tissue imaging (Loeb et al.”
- Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans” (2018, background): “Since AuNPs are non-toxic to the host (Conde et al., 2014; Li et al., 2014; Rajchakit and Sarojini, 2017), the possibility of fine tuning their conjugation chemistry to act as carriers or delivery vehicles of antibiotics or other antibacterial moieties may enhance their bactericidal effect and poten”