Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

By C. Anacker, R. Hen. Nature Reviews Neuroscience, 2017

902 citations recorded by the source corpus.

Adult hippocampal neurogenesis has been implicated in cognitive processes, such as pattern separation, and in the behavioural effects of stress and antidepressants. Young adult-born neurons have been shown to inhibit the overall activity of the dentate gyrus by recruiting local interneurons, which may result in sparse contextual representations and improved pattern separation. We propose that neurogenesis-mediated inhibition also reduces memory interference and enables reversal learning both in neutral situations and in emotionally charged ones. Such improved cognitive flexibility may in turn help to decrease anxiety-like and depressive-like behaviour.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/7b88b6aeafe543e8d1e9cfcc6b9fefbf7e641375

Citations in the corpus

• Temporal Interference Stimulation Enhances Neural Regeneration (2026, unknown): “The presence of endogenous theta oscillations in developing brain organoids [ 109 ] and adult brains [ 142, 15 ] further suggests their conserved role in neurogenesis across life stages.”