Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited.

By Antonio Ceriello, E. Motz. Arteriosclerosis, Thrombosis and Vascular Biology, 2004

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Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes (2012, background): “Key mechanisms of hyperglycemia-induced inflammation include nuclear factor-kB–dependent production of proinflammatory cytokines, Toll-like receptor (TLR) expression, increased oxidative stress, and inflammasome activation (4,5).”
Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). (2015, neutral): “It is suggested that this excessive oxidative stress may be the pathogenic mechanism underlying insulin resistance, diabetes and CVD [58,59].”
Postprandial hyperglycemia and diabetes complications: is it time to treat? (2005, background): “However, evidence suggests that postprandial hypertriglyceridemia and hyperglycemia independently induce endothelial dysfunction through oxidative stress (80).”