A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells.

By Ivraym B. Barsoum, Chelsea A. Smallwood, D. Siemens, C. Graham. Cancer Research, 2014

656 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/7b6e6e2ca25f7d6c8de48d009f8a97351ca789d8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. V. Nizet
2. Yongqian Shu
3. Ke Wei
4. A. Palazón
5. Xinming Jing
6. Richard J. Johnson
7. C. Shao
8. C. Wigerup

In Immunology

1. Xu Dong Zhang
2. M. Hung
3. Richard J. Johnson
4. Lei Jin
5. J. Hsu
6. Chia‐Wei Li
7. Jong-Ho Cha
8. Jiezhong Chen

Citations in the corpus

• HIF Transcription Factors, Inflammation, and Immunity (2014, background): “, 2013) and HIF-1a also increases PD-L1 expression on hypoxic cancer cells to promote immune escape (Barsoum et al., 2014).”
• Mechanisms controlling PD-L1 expression in cancer (2019, background): “Besides MYC and ALK, the HIF1/2α, NF-κB, MAPK, PTEN/PI3K and EGFR oncogenic pathways can also boost PD-L1 mRNA expression when they are mutated or hyperactivated (Akbay et al., 2013; Atefi et al., 2014; Barsoum et al., 2014; Jiang et al., 2013; Peng et al., 2015; Xu et al., 2014).”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “Hypoxia can also suppress dendritic cell function and inhibit infiltrating cytotoxic T-lymphocyte activity in a HIF-1αdependent manner (Barsoum et al., 2014; Palazon et al., 2012).”
• PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy (2015, background): “Other factors in the tumor metabolic microenvironment, including hypoxia, can result in PD-L1 upregulation and are dependent on signaling via HIF1a (61).”
• Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “A recent study showed the upregulation of the expression of programmed death-ligand 1 (PD-L1) under hypoxia [59].”
• ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, neutral): “…factor b [TGF-b] and VEGF) induced by hypoxia or acidosis suppress the activity of T lymphocytes and inhibit the ability of dendritic cells to process tumor antigens and present them to lymphocytes (Barsoum et al., 2014; Calcinotto et al., 2012; Gabrilovich et al., 2012; Palazón et al., 2012).”
• Regulation of PD-L1: a novel role of pro-survival signalling in cancer. (2016, background): “Increased HIF-1 levels are associated with increased PD-L1 expression and cause down-regulation of T-Cell function[66-71], suggesting hypoxic environments, which leads to increased expression of HIF-1, can also result in immune suppression in addition to promoting cell proliferation and blocking apo”