The individual and socioeconomic impact of osteoarthritis

By D. Hunter, D. Schofield, E. Callander. Nature Reviews Rheumatology, 2014

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The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “Currently, OA is the leading cause of disability in older adults, and affects more than 250 million people worldwide, and represents a substantive burden to health care systems (Hunter et al., 2014).”
Curcumin: A Review of Its’ Effects on Human Health (2017, background): “It affects over 250 million people worldwide, leading to increased healthcare costs, impairment in activities of daily living (ADL), and ultimately decreased quality of life [31,32].”
Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019 (2022, background): “5% of national gross domestic product was attributed to the medical costs of OA, while the indirect costs, including work loss and premature retirement, were not taken into consideration (1,20).”