The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis

By David D. Boehr, Dan McElheny, H. J. Dyson, Peter E. Wright. Science, 2006

926 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7b1f49a2062f20ea9d8b38beb557992dacd9fa4b

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In Molecular Biology

1. Peng Sang
2. Jean-Pierre Eckmann
3. Tsvi Tlusty
4. Xing Du
5. Jing Liang
6. Yi Li
7. Xing-lai Ji
8. Albert Libchaber

Citations in the corpus

• Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods (2016, background): “Third, the formation of the protein–ligand complex alters the heights of the free energy barriers (or the conformational transition rates) that separate the bound state/substate and its adjacent states/substates, thus resulting in a population shift towards the bound state/substate and the conformat”
• Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get” (2009, neutral): “…Can Lose Internal Freedom and Entropy Some simple models assume that the ligand entropy lost on binding correlates with the number of rotatable bonds in the ligand (Böhm, 1993; Gilson and Zhou, 2007; Huey et al., 2007; Laederach and Reilly, 2003; Taylor et al., 2002; Gohlke and Klebe, 2002).”
• Green function of correlated genes in a minimal mechanical model of protein evolution (2018, background): “The perturbation expansion directly links long-range epistasis to shear deformation: Near the transition, the Green function is dominated by the soft mode, G ' u∗u ∗/λ∗, with fitness F given by [4].”
• The Importin β Binding Domain as a Master Regulator of Nucleocytoplasmic Transport (2010, background): “Conformational selection has been shown to play an important role in enzyme catalysis [82] and protein association reactions involving binding to small molecule ligands, other proteins,”
• Allostery and cooperativity revisited (2008, neutral): “…chaperonin, GroEL, a Allostery and cooperativity revisited www.proteinscience.org 1299 JOBNAME: PROSCI 17#8 2008 PAGE: 5 OUTPUT: Saturday July 12 02:45:06 2008 csh/PROSCI/164284/ps032599 large protein shaped like a double-ring (Boisvert et al. 1996; Xu et al. 1997; Grallert and Buchner 2001).”