Malaria in 2002

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Genome sequence of the human malaria parasite Plasmodium falciparum (2002, background): “Fifty-two per cent of the predicted gene products (2,731) were detected in cell lysates prepared from several stages of the parasite life cycle by high-resolution liquid chromatography and tandem mass spectrometry(14,15), including many predicted proteins with no similarity to proteins in other orga”
Climate Change Futures: Health, Ecological and Economic Dimensions (2004, background): “Population migrations, deforestation, drug and pesticide resistance also contribute and public health infrastructure has deteriorated in many countries (Githeko and Ndegwa 2001; Greenwood and Mutabingwa 2002).”
Malaria: progress, perils, and prospects for eradication. (2008, positive): “…first-line antimalarials chloroquine and sulfadox-ine-pyrimethamine (53–55) has had a devastating impact on malaria treatment and control and has spurred multiple investigations into the development of new antimalarials, with an emphasis on artemis-inin-based combination therapies (ACTs) (56, 57).”
Antimalarial drug discovery: efficacy models for compound screening (2004, background): “Figure 1 | The global distribution of malaria, showing areas where Plasmodium falciparum resistance to the most commonly used antimalarial drugs, chloroquine and sulphadoxine-pyrimethamine, has been documented. Resistance is now widely disseminated throughout malaria-endemic regions (coloured in red”