Toxicology rethinks its central belief

By Edward J. Calabrese, L. A. Baldwin. Nature, 2003

679 citations recorded by the source corpus.

Subfields: Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/7a820990e8a06ddb90346550b126b6ea1bacf44b

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Citations in the corpus

The nature of nutrition: a unifying framework (2011, background): “Hormesis is a concept developed in toxicology, in which the effects on biological systems (cells, tissues, organs, organisms, populations) of exposure to a substance are reversed with increasing concentration (Calabrese and Baldwin 2003).”
How Do Nutritional Antioxidants Really Work: Nucleophilic Tone and Para-Hormesis Versus Free Radical Scavenging in vivo (2013, positive): “Regardless, the sole mechanism that has been reported to reduce carcinogenesis in animals exposed to ionizing radiations is previous exposure to low-level radiations, which likely works through enhancing DNA repair and adaptive defense mechanisms [24, 25].”
Bioassay analysis using R (2005, methodology): “Besides the Weibull model and the logistic model, Brain-Cousens’ model (Brain & Cousens, 1989) is used in situations where hormesis is present: For small doses the herbicide has the adverse eect resulting in response values above the level of the control group ( Calabrese & Baldwin, 2001, 2003 ).”
The role of animal behaviour in the study of endocrine-disrupting chemicals (2004, critical): “Some ecotoxicologists believe that nonlinear dose–response relationships are underreported because of their deviation from toxicology dogma (Calabrese & Baldwin 2003).”
Dissolved humic substances – ecological driving forces from the individual to the ecosystem level? (2006, background): “It is essential to note that there is increasing awareness that mild chemical stresses (in the socalled hormetic dose or concentration range) may even be beneficial at both the individual (Calabrese & Baldwin, 2003; Le Bourg, 2003; Calabrese, 2005) and population levels (Rattan, 2004).”
Environmental hormesis, a fundamental non-monotonic biological phenomenon with implications in ecotoxicology and environmental safety (2018, background): “…termed by Southam and Ehrlich (1943), satisfies the evaluation criteria and should serve as the default model in risk assessment of carcinogens and noncarcinogens for the purposes of regulatory agencies (Calabrese and Baldwin, 2003a, 2003b; Calabrese, 2004, 2005, 2015; Cook and Calabrese, 2006).”
Utilizing R Software Package for Dose-Response Studies: The Concept and Data Analysis (2007, background): “Hormesis (from the Greek for ‘‘setting in motion’’), is a stimulation of plant response to a low dose of some herbicides, resulting in response values that are higher than in nontreated plants (Calabrese 2001; Calabrese and Baldwin 2001, 2003).”