Tumor metastasis: moving new biological insights into the clinic

By Liling Wan, K. Pantel, Yibin Kang. Nature Medicine, 2013

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EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “microenvironment, metastatic growths seem equally reliant on stromal support (Hanahan and Coussens, 2012; Quail and Joyce, 2013; Wan et al., 2013).”
Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration (2015, background): “The process of local invasion can be active since tumour cells can secrete Matrix Metalloproteinases (MMPs) that dissolve the lamina propria [21].”
New horizons in tumor microenvironment biology: challenges and opportunities (2015, background): “Tumors not only preferentially select proclivity sites for metastasis, but exhibit variable dormancy length in temporary course [31], both as important facets to be considered for improved drug design and treatment strategy to thwart disease exacerbation at each individual stage.”
Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics (2016, background): “The metastasis of cancer cells is a multistep process, which includes the migration and invasion from primary tumor, intravasation and survival in the circulation system, and extravasation into distant tissues and establishing metastatic foci in the seeded organs [9, 30].”