Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.

By Yanqiu Chen, M. Cann, Tatiana N. Litvin, V. Iourgenko, Meeghan L. Sinclair, L. Levin, J. Buck. Science, 2000

882 citations recorded by the source corpus.

Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated by cyclic adenosine 3',5'-monophosphate (cAMP). It has been assumed that bicarbonate mediates its effects through changes in intracellular pH or membrane potential; however, we demonstrate here that bicarbonate directly stimulates mammalian soluble adenylyl cyclase (sAC) activity in vivo and in vitro in a pH-independent manner. sAC is most similar to adenylyl cyclases from cyanobacteria, and bicarbonate regulation of cyclase activity is conserved in these early forms of life. sAC is also expressed in other bicarbonate-responsive tissues, which suggests that bicarbonate regulation of cAMP signaling plays a fundamental role in many biological systems.

Subfields: Cell Biology, Public Health, Environmental and Occupational Health, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/7a60f20ec2a5cd6835814eb47863f10b793cffc0

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In Cell Biology

1. J. Raven
2. John Beardall

Citations in the corpus

• Carbon Acquisition Mechanisms of Algae: Carbon Dioxide Diffusion and Carbon Dioxide Concentrating Mechanisms (2003, background): “Other algae have one (dinophyte, euglenoid) or two (ch1orarachniophyte, cryptophyte, haptophyte and heterokont) additional chloroplast envelope membranes which are fre­ quently, but incorrectly, termed chloroplast endo­ plasmic reticulum ( Cavalier-Smith, 2000 ).”